In rat studies, exposure to total atorlip-ez ezetimibe in nursing pups was up to half of that observed in maternal plasma.

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Colstipol: Plasma concntations atovastatin and its activ mtabolits w low (by appox. 25%) whn colstipol was co-administd with atovastatin. Howv, lipid cts w gat whn atovastatin and colstipol w co-administd than whn ith mdicinal poduct was givn alon.

Glycopotin IIb/IIIa Inhibitos: ATOLIP CV should b usd with caution in patints whciv concomitant glycopotin IIb/IIIa inhibitos.

Niacin: Th isk skltal muscl cts may b nhancd whn Ophthacare how much atovastatin is usd in combination with niacin; a duction in ATOLIP CV dosag should b considd in this stting.

Atovastatin is a slctiv, comptitiv inhibit3-hydoxy-3-mthylglutayl-conzym A (HMG-CoA) ductas, th at-limiting nzym that convts 3-HMG-CoA tmvalonat, a pcusstols, including cholstol. Cholstol and tiglycids (TG) ciculat in th bloodstam as pat lipopotin complxs. With ultacntiugation, ths complxs spaat inthigh-dnsity lipopotin (HDL), intmdiat-dnsity lipopotin (IDL), low-dnsity lipopotin (LDL) and vy-low-dnsity lipopotin (VLDL) actions. TG and cholstol in th liv a incopoatd intVLDL and lasd intth plasma dlivy tpiphal tissus. LDL is omd om VLDL and is catabolizd pimaily though th high-ainity LDL cpto.

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