Advise patients 1 to avoid operating automobiles and machinery or engaging in other tasks requiring alertness until the patient s response to therapy with toprol-xl has been determined; 2 to contact the physician if any difficulty in breathing occurs; 3 to inform the physician or dentist before any type of surgery that he or she is taking toprol-xl.

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Your doctor may want you to gradually reduce the amount of TOPROL-XL you are taking before stopping completelyThis may help reduce the possibility of your condition worsening or other heart complications occurring.

Elevated systolic or diastolic pressure causes increased cardiovascular riskand the absolute risk increase per mmHg is greater at higher blood pressuresso that even modest reductions of severe hypertension can provide substantial benefitRelative risk reduction from blood pressure reduction is similar across populations with varying absolute riskso the absolute benefit is greater in patients who are at higher risk independent of their hypertensionfor examplepatients with diabetes or hyperlipidemiaand such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal.

Do not give TOPROL-XL to anyone else even if they have the same condition as you.

If any of the following happentell your doctor or go to Accident and Emergency at your nearest hospital immediately:

If you feel a worsening of your condition in the early stages of taking TOPROL-XLtell your doctor immediately.

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