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The level of phenytoin should be carefully monitored in patients taking XELODA and phenytoin dose may need to be reducedsee DOSAGE AND ADMINISTRATIONPostmarketing reports indicate that some patients receiving XELODA and phenytoin had toxicity associated with elevated phenytoin levelsFormal drug-drug interaction studies with phenytoin have not been conductedbut the mechanism of interaction is presumed to be inhibition of the CYP2C9 isoenzyme by capecitabine and/or its metabolites.
Surgery and radiation therapy for breast cancer are classified as local treatments since they are focused on treating the cancer without harming the rest of the bodywhile systemic treatmentslike chemotherapyhormone therapytargeted therapyand bone-directed therapyare focused on the use of drugs to reach and destroy cancer cells in the body.
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