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At least 14 days should elapse between discontinuation of an MAOI intended to treat psychiatric disorders and initiation of therapy with SARAFEMConverselyat least 5 weeks should be allowed after stopping SARAFEM before starting an MAOI intended to treat psychiatric disorderssee CONTRAINDICATIONS
Anaphylactoid reactionsincluding bronchospasmangioedemalaryngospasmand urticaria alone and in combinationhave been reported.
The potential for interaction by a variety of mechanismsfor examplepharmacodynamicpharmacokinetic drug inhibition or enhancementetcis a possibility.
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events associated with discontinuation for sarafem 20 mg continuous and intermittent pooled, sarafem 60 mg continuous, and pooled placebo, respectively, were anxiety 0 , 6 , and 1 ; nervousness 1 , 0 , and 0.