Viramune co-administration did not alter the ovulation suppression effects of dmpa.

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If clinical hepatitis occurscharacterised by anorexianauseavomitingicterus AND laboratory findingssuch as moderate or severe liver function test abnormalitiesexcluding GGTnevirapine must be permanently stoppedViramune must not be readministered to patients who have required permanent discontinuation for clinical hepatitis due to nevirapine.

It is not recommended to coadminister boceprevir and Viramunesee section 4.4

Data on the effectiveness of nevirapine in subsequent regimens are limitedSubsequent regimens using NNRTIs appear most effective in individuals who have not previously experienced virologic failure while using drugs of this class.

The safety and efficacy of Viramune has not been established in patients with significant underlying liver disordersViramune is contraindicated in patients with severe hepatic impairmentChild-Pugh Csee section 4.3Pharmacokinetic results suggest caution should be exercised when nevirapine is administered to patients with moderate hepatic dysfunctionChild-Pugh BPatients with chronic hepatitis B or C and treated with combination antiretroviral therapy are at an increased risk for severe and potentially fatal hepatic adverse reactionsIn the case of concomitant antiviral therapy for hepatitis B or Cplease refer also to the relevant product information for these medicinal products.

For more information about treatment with Viramuneread the package leafletalso part of the EPARor contact your doctor or pharmacist.

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